HETEROTRANSPLANTATIONS AND GENOMIC IN CANCER RESEARCH
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https://doi.org/10.46545/aijcs.v3i1.220Keywords:
HETEROTRANSPLANTATIONS, GENOMIC, CANCERAbstract
We performed ,in 1975, the first heterotransplantation of invertebrate A.O in nude mouse, then a double heterotransplantation of human tumor and Axial organ next to this last one, always in nude mouse: The human tumor was rejected in 50% of observed cases.Some
years later, we found that A.O cells exerted an induced and spontaneous cytotoxicity against SP2 and MBL2 mouse tumoral cells.Recently, we discovered a sea star Igkappa gene with immune properties. This gene was inserted in a CMV(cytomegalovirus) and finally in a plasmid called « young » plasmid.
The induced« young » protein exerted a spontaneous cytotoxicity against osteosarcom cells (U2oS cells) against A-375 melanome cells and Hela cells
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References
Fen Chen et al. (2006). Mol. Cancer Ther. 5(1).
Flanagan, M. et al. (2011). Cancer Gene Ther. 18(8), 579-586.
Leclerc, M. et al. (1975). Transplantation, 74-76.
Luquet, G., & Leclerc, M. (1983). Immunol.Lett. 6, 107-108.
Vincent, N. et al. (2014). 2, 320-322.
Leclerc, M., & Otten, P. (2014). SAJ Biotechnology, 1, 104.
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Copyright (c) 2021 Michel Leclerc
This work is licensed under a Creative Commons Attribution 4.0 International License.
